What happens when valproic acid level is low

    when should depakote level be drawn
    when should depakote level be drawn after starting
    how often should depakote level be drawn
    when should valproic acid level be drawn
  • When should depakote level be drawn

    • Signs of high depakote level.

    Sir,

    Divalproex sodium extended release (ER) preparations received Food and Drug Administration approval as monotherapy for management of acute mania in 2005.[1] It is intended for once daily (OD) oral administration and maintains a steady state plasma concentration for 24 h.[2] The therapeutic range is maintained through controlling its release.

    Valproic acid levels for bipolar disorder

  • Valproic acid levels for bipolar disorder
  • What happens if depakote levels are too high
  • Signs of high depakote level
  • Valproic acid trough level
  • Normal valproic acid serum level

    • Therapeutic efficacy is associated with a trough level concentration between 50 and 100 mmol/L (trough levels). Though it does not have a narrow therapeutic range as in the case of lithium, accurate estimation of its trough level is essential as any value below the lower limit of the therapeutic range is not effective and above it may result in adverse effects.[3] Trough levels are more accurate when measured just before the next dose.

    After a once-daily divalproex-ER dose, the timing of the blood sample does matter and impacts the proper interpretation of the valproic acid (VPA) concentration. There is no one consensus that we depend upon for an optimal time to estimate the trough levels, which impacts the proper interpretation of the

      when should depakote levels be checked
      how often should depakote level be checked